LACTIC ACIDOSIS : A POORLY UNDERSTOOD CONCEPT

Thrombosis – Besieged but Poorly Understood

In biology, thrombosis is a mechanism of maintaining the integrity of biological surfaces in higher mammals, limiting fluid loss, and facilitating the recognition, containment, and destruction of pathogens and foreign materials by a scaffold of fibrin and DNA strands. However, thrombosis may also lead to vascular occlusion and subsequent tissue damage. In medicine, thrombosis is a hallmark of l...

Premenstrual asthma: still poorly understood.

Nephrogenic ascites: a poorly understood syndrome.

Nephrogenic ascites is a condition characterized by the presence of massive ascites in a patient with ESRD. Neither the exact cause nor the pathogenesis of ascites formation is clearly understood. Patients frequently present with hypertension, moderate to massive ascites, minimal extremity edema, cachexia, and a history of dialysis-associated hypotension. The ascitic fluid is typically an exuda...

Lactic Acidosis

Lactic acidosis is a form of metabolic acidosis due to the inadequate clearance of lactic acid from the blood. Lactate is a byproduct of anaerobic respiration and is normally cleared from the blood by the liver, kidney and skeletal muscle. Lactic acidosis occurs when the body's buffering systems are overloaded and tends to cause a pH of ≤7.25 with plasma lactate ≥5 mmol/L. It is usually caused ...

Lactic acidosis.

A 33-year-old male was admitted to Michael Reese Hospital and Medical Center for evaluation of weight loss, dyspnea, and fever. He had factor Vill-deficient hemophilia and had been chronically ill over several months with a cough productive of scanty sputum, weight loss of 15 Ibs, low-grade fever, and progressive dyspnea on exertion. The medical history was notable for right total hip replaceme...